The NMDA Receptor NR1, Splice Variant N1 (N-methyl-D-aspartate Receptor Subunit NR1, NMD-R1, NMDAR1, Nmdar, NR1, Glutamate [NMDA] Receptor Subunit zeta-1, Grin1, GluRdelta1, GluRzeta1, Glurz1, M100174, Rgsc174) Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Rat antigen. The NMDA Receptor NR1, Splice Variant N1 (N-methyl-D-aspartate Receptor Subunit NR1, NMD-R1, NMDAR1, Nmdar, NR1, Glutamate [NMDA] Receptor Subunit zeta-1, Grin1, GluRdelta1, GluRzeta1, Glurz1, M100174, Rgsc174) Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
N-methyl-D-aspartate receptor (NMDAR) forms a heterodimer of at least one NR1 and one NR2A-D subunit. Multiple receptor isoforms with distinct brain distributions and functional properties arise by selective splicing of the NR1 transcripts and differential expression of the NR2 subunits. NR1 subunits bind the co-agonist glycine and NR2 subunits bind the neurotransmitter glutamate.
NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning. NMDA receptors are also implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism